实验室生化和血液学参数:用于诊断C型肝炎病毒感染的早期预测生物标志物
Saeede Bagheri1, Ghazaleh Behrouzian Fard1, Nasrin Talkhi2
1Department of Laboratory Sciences, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of clinical laboratory analysis
|November 21, 2024
概括
生物化学和血液学标记可以帮助诊断C型肝炎病毒 (HCV) 感染. 淋巴细胞计数和血小板与淋巴细胞比率 (PLR) 等关键指标在HCV患者中显示出显著差异,有助于早期检测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床生物化学 临床生物化学
- 血液学 血液学 血液学
背景情况:
- 型肝炎病毒 (HCV) 感染是一个全球性的健康问题,需要及早检测,以防止肝损伤和传播.
- 生物化学和血液学参数可以作为炎症的有价值指标,帮助诊断HCV感染.
研究的目的:
- 研究HCV患者和健康个体之间的显著生化和血液学差异.
- 确定可靠的生物标志物,用于早期诊断C型肝炎病毒感染.
主要方法:
- 分析了来自HCV阳性高风险患者的100个样本 (通过qPCR确认) 和100个HCV阴性对照.
- 抗HCV标位,生物化学测试,炎症标志物和完整血细胞计数 (CBCs) 的表现.
- 使用的接收器操作特征 (ROC) 曲线来确定实验室参数的截止值.
主要成果:
- 在HCV患者中,WBC,ESR,CRP,LDH, bilirubin,ALP,SGPT和ferritin的水平显著更高.
- 与对照组相比,在HCV患者中观察到红细胞,中性粒细胞,淋巴细胞,HPR和铁的水平较低.
- ROC分析确定了淋巴细胞计数,中性粒细胞计数和PLR作为HCV感染的高度准确预测指标 (AUC=1).
结论:
- 在HCV感染个体和健康个体之间,生物化学和血液学概况存在显著差异.
- 已识别的生物标志物对于早期诊断HCV至关重要.
- 早期诊断可以帮助预防肝损伤并减少HCV的传播.
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