增强乙型肝炎病毒的表观遗传抑制由干扰素-α和小干扰RNA协同作用的共闭环形DNA

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Kongying Hu1, Wenjing Zai1, Mingzhu Xu1

  • 1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Research Unit of Cure of Chronic Hepatitis B Virus Infection (CAMS), Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, School of Basic Medical Sciences, Shanghai Medical College Fudan University, Shanghai, China.

mBio
|November 21, 2024
PubMed
概括

使用干扰素 (IFN) 和小干扰RNA (siRNA) 的组合疗法提供了一种强有力的策略,可以在表观遗传上抑制乙型肝炎病毒 (HBV) 协同封闭圆形DNA (cccDNA) 持久性. 这种方法在临床前模型中显示,与单一治疗相比,病毒活动的抑制效果优越且持续.

关键词:
这就是HBV HBV.国际货币基金组织 IFN IFNcccDNADNA 在线阅读组合疗法治疗组合治疗.表观遗传调制是一种表观遗传调制.siRNA 是一个RNA.

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