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Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

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Published on: October 20, 2018

在芯片上设计和评估血管化的器官类型球体.

James J Tronolone¹, Nadin Mohamed¹, Christopher P Chaftari¹

¹Department of Biomedical Engineering, College of Engineering, Texas A&M University, College Station, Texas.

Current protocols

|November 21, 2024

概括

这项研究为血管化有机型球体提供了一个标准化的协议,这对于先进的体外模型至关重要. 该指南确保了研究人员开发基于血管化的有机体的微生理学平台的可重复性.

关键词:

微生理系统的微生理系统.这是一种有机物质的有机物质.器官芯片是一个器官芯片.球形形状的球形状血管化的血管化.

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科学领域:

生物技术是生物技术.
组织工程是组织工程.
微流体学微流体学

背景情况:

器官类型球体在体外模型中是有价值的,但为了生理相关性,需要血管化.
目前的血管化方法缺乏标准化和可重复性,限制了它们的广泛采用.
制定标准化的协议对于推进基于有机体的研究至关重要.

研究的目的:

为提供一个详细的,逐步指南,以血管化有机型球形.
标准化微流体芯片设计,球形制造和血管化技术的协议.
提高血管化的有机体模型的可复制性和采用性.

主要方法:

微流体芯片的设计和制造.
有机型球形制造技术.
通过血管生成和血管生成进行血管化,包括分子分析和计算建模.

主要成果:

这里介绍了一种系统的方法来血管化有机型球体 (胰腺小岛和癌症球体).
协议涵盖了芯片设计,球形制造和芯片上的血管化.
包括表征,量化和大众运输分析的方法.

结论:

开发的协议有助于在血管化有机体研究中的标准化和可重复性.
本指南旨在促进研究人员采用基于有机体的微生理学平台.
标准化的血管化是改善体外模型寿命,稳定性和相关性的关键.