侧侧内皮层的 afferents 重构了皮质状皮层电路中的活动
Olivia Pedroncini1, Noel Federman1, Antonia Marin-Burgin1
1Instituto de Investigación en Biomedicina de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas-Partner Institute of the Max Planck Society, Buenos Aires C1425FQD, Argentina.
概括
侧腔内耳皮层 (LEC) 通过调节神经活动和整合空间背景来影响皮层 (PCx) 气味处理. 这项研究揭示了LEC输入如何塑造PCx微电路内的嗅觉反应.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统研究 嗅觉系统研究
- 空间导航 空间导航
背景情况:
- 皮质皮质 (PCx) 中的气味表现编码空间上下文.
- 大脑的起源和将这些空间信息整合到PCx中的机制仍然不清楚.
研究的目的:
- 研究侧腔内耳皮层 (LEC) 作为影响PCx微电路和嗅觉反应的空间背景的来源.
- 阐明LEC输入如何调节PCx神经元活动并与嗅觉感官输入相互作用.
主要方法:
- 在小鼠大脑切片中的贴片记录,准表面 (SP) 和深层 (DP) 的金字塔神经元,以及抑制帕瓦尔胺 (PV) 和索马托斯塔丁 (SOM) 的内部神经元.
- 激发性LEC投射的光遗传刺激,以评估它们对PCx活性的影响.
- 检查了LEC输入和侧侧嗅道 (LOT) 感觉信号之间的相互作用.
主要成果:
- 在PCx中,LEC输入分布异质,SP和PV神经元中的激发电流更强.
- LEC输入差异调节抑制电路,激活PV并抑制SOM内部神经元.
- 同时的LEC和LOT激活增强SP和DP神经元的尖峰,通过LEC诱导的抑制延迟的LOT引起的尖峰,提高DP反应.
结论:
- 通过调节神经元兴奋性和抑制电路,LEC附带物重新配置PCx活性.
- LEC输入激活PV内部神经元,这表明一种抑制反复活动和调节嗅觉反应的机制.
- 这些发现有助于了解PCx如何整合嗅觉和非嗅觉信息以形成气味对象表示.
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