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Updated: Jun 15, 2026

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
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An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

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拉索帕蒂相关突变Ptpn11D61Y对突触水囊回收有年龄依赖的影响

Debarpan Guhathakurta1, Franziska Selzam2,3, Aneta Petrušková1,4,5

  • 1Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Cellular and molecular neurobiology
|November 21, 2024
PubMed
概括

像努南综合症这样的拉索病症会破坏大脑功能. 这项研究表明,PTPN11变体损害了成熟小鼠神经元中的突触囊泡贩运,影响神经传递和潜在的认知缺陷.

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Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...