慢性感染HIV-1阳性个体的认知衰老加速,尽管有效的长期抗逆转录病毒疗法
Hemalatha Babu1, Gladys Rachel1,2, Ujjwal Neogi3
1Department of Virology and Biotechnology, ICMR-National Institute for Research in Tuberculosis, Chennai, 600031, India.
Metabolic brain disease
|November 21, 2024
概括
艾滋病毒感染者经常面临加速的神经衰老和认知障碍,即使有有效的治疗. 这项研究揭示了病毒抑制个体的显著神经认知缺陷,突出了需要更好的长期艾滋病毒管理策略.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 老年学是一门学科.
背景情况:
- 艾滋病毒感染者 (PLHIV) 面临与年龄相关疾病的风险增加,即使使用联合抗逆转录病毒疗法 (cART).
- 慢性艾滋病毒感染对病毒抑制个体神经认知功能的影响仍然是研究的关键领域.
研究的目的:
- 为了评估病毒抑制的PLHIV的神经认知功能.
- 通过蛋白质组和代谢组分析,研究艾滋病毒感染与神经系统变化之间的关联.
主要方法:
- 使用国际艾滋病毒痴呆症量表 (IHDS) 进行神经心理评估.
- 通过使用Olink®神经探索面板进行近距离延伸试验 (PEA) 进行等离体蛋白质组分析.
- 使用超高性能液体染色学/质谱学/质谱学的非向代谢学.
主要成果:
- 很大一部分 (71%) 的PLHIV患者表现出无症状的神经认知障碍 (IHDS得分≤10) 尽管有9年的cART和抑制的病毒病.
- 在PLHIV中观察到蛋白质和代谢物水平的改变,与神经炎症,神经退行,认知障碍和胃肠道癌症有关.
- 临床和实验室证据支持PLHIV无症状神经认知障碍,表明神经衰老加速.
结论:
- 艾滋病毒感染加大了加速神经衰老的风险,即使有有效的cART和无法检测到的病毒病.
- 无症状神经认知障碍在PLHIV中很普遍,需要针对性干预.
- 这些发现强调了制定战略的重要性,以改善艾滋病毒感染者的长期管理.
相关概念视频
Retrovirus Life Cycles
45.7K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.7K
Cognitive Development During Adulthood
55
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
55
Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
Alzheimer's Disease: Overview
448
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
448
Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37


