口腔潜在恶性疾病患者的瘤学结果
Alessandro Villa1,2, Michele Lodolo1, Patrick Ha3
1Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco.
JAMA otolaryngology-- head & neck surgery
|November 21, 2024
概括
口腔潜在恶性疾病 (OPMDs) 呈现出不同程度的口腔癌进展率. 早期检测和每个OPMD的独特管理策略对于改善患者生存至关重要.
科学领域:
- 口腔瘤学 在口腔瘤学
- 牙科医学 牙科医学
- 癌症流行病学癌症流行病学
背景情况:
- 口腔潜在恶性疾病 (OPMDs) 需要了解早期口腔癌检测.
- 关键的OPMD包括口腔白血病,红血病,下纤维化和平坦.
研究的目的:
- 为了评估OPMDs恶性转化率变成口腔癌.
- 用美国大型电子健康数据库识别与OPMD进展相关的因素.
主要方法:
- 使用UCSFPatientExploreR数据库 (1973-2024) 的回顾性队列研究.
- 使用ICD-10代码和关键词识别了OPMD.
- 使用后勤回归分析人口统计,风险因素 (烟草,酒精,艾滋病毒) 和恶性转变.
主要成果:
- 在4371名口腔癌患者中,110名 (2.5%) 患有先前的OPMD.
- 口腔白血病显示8.4%的转化率;口腔红血病显示50.0%.
- 患有口腔白血病的HIV阳性患者的口腔癌风险较高 (OR 3.80).
结论:
- OPMDs表现出不同的恶性转变潜力.
- 基于OPMD类型的个性化监控和管理至关重要.
- 承认OPMD作为独立实体对于有效的患者护理至关重要.
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