人类骨肌具有高强度间歇训练的表观遗传记忆
Andrea M Pilotto1, Daniel C Turner2, Raffaele Mazzolari3
1Department of Molecular Medicine, University of Pavia, Pavia, Italy.
American journal of physiology. Cell physiology
|November 21, 2024
概括
人类骨肌在高强度间歇训练 (HIIT) 后保留了表观遗传记忆. 这种肌肉记忆,涉及DNA甲基化变化,通过解除训练和重新训练持续存在,增强基因表达.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 骨肌肉表现出表观遗传记忆在抵抗运动诱导的缩后.
- 在高强度间歇训练 (HIIT) 后表观遗传记忆的存在仍然未被探索.
- 了解肌肉记忆机制对于优化训练和解除训练协议至关重要.
研究的目的:
- 调查高强度间歇训练 (HIIT) 是否会诱导人类骨肌肉中的表观遗传记忆.
- 评估这种表观遗传记忆在脱训期间的持久性及其对重新训练的影响.
- 为了确定特定的基因和分子途径参与HIIT诱导的肌肉记忆.
主要方法:
- 20名健康受试者接受了两个为期2个月的HIIT干预,分开3个月的训练期.
- 测量了最大的氧气消耗 (VO2max),以及巨大的横向肌肉活检.
- 进行了全基因组DNA甲基化和向基因表达分析.
主要成果:
- HIIT导致了广泛的DNA低甲基化,在去训练3个月后仍然存在.
- 五个基因 (ADAM19,INPP5a,MTHFD1L,CAPN2,SLC16A3) 显示持续的低甲基化和增加的表达.
- 保持低甲基化与增强的基因表达相关,特别是对于参与乳酸运输和信号传递的基因.
结论:
- 人类骨肌具有强大的表观遗传记忆,用于高强度间歇训练 (HIIT).
- 这种记忆的特点是保持DNA低甲基化和在训练过程中改变基因表达特征.
- 与乳酸运输和信号传递相关的特定基因似乎是HIIT诱导的肌肉记忆的核心.
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