在经历无家可归的人群中增加了多药耐药Shigella sonnei感染的严重程度
Aleksandra Stefanovic1,2, Mosaab E Alam3, Nancy Matic1,2
1Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
概括
希格拉·索尼菌感染率显著增加,从与男性发生性关系的男性转移到无家可归的人群. 一种多药耐药的克隆导致更严重的甲菌病,特别是在弱势群体中.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 基因组学就是基因组学.
背景情况:
- 石格拉·索尼 (Shigella sonnei) 与与男性发生性关系的男性 (MSM) 发生性传播的肠道感染有关.
- 在无家可归者 (PEH) 中观察到多抗药性 (MDR) Shigella sonnei细菌病的增加.
研究的目的:
- 调查Shigella sonnei感染的流行病学变化,临床结果和基因组特征.
- 了解传播模式的转变和耐药菌株的出现.
主要方法:
- 从2015年到2022年,对163个Shigella sonnei病例进行了回顾性审查.
- 在两个时期收集的人口统计,临床表现和微生物学数据:2015-2020年和2021-2022年.
- 全基因组测序用于识别基因型和抗菌素耐药性模式.
主要成果:
- 西格拉·索尼菌感染从每年8.3个病例增加到每年56.5个病例,主要受影响人群从MSM转向PEH.
- 在最近的时期,严重的石病率显著增加 (61%与14%相比).
- 一种主导的多药耐药克隆 (3.6.1.1.2) 出现了,它对大多数药物具有耐药性,但对 ceftriaxone 敏感.
结论:
- 在PEH中观察到严重的甲状病毒病的大量增加和从性传播到环境传播的转移.
- 一种特定的MDR Shigella sonnei克隆的出现与PEH中更严重的疾病有关,可能是由于人口的脆弱性.
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