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将双重口服药物加上胰岛素与胰岛素进行比较 在不受控制的II型糖尿病中使用三重口服药物:试点研究
Nadia Gul1, Inayat Ur Rehman1,2, Yasar Shah1
1Department of Pharmacy, Garden Campus, Abdul Wali Khan University Mardan, Mardan, Pakistan.
PloS one
|November 21, 2024
概括
对于未经双重口服药物控制的II型糖尿病 (T2DM) 患者,三重口服低血糖药物 (OHA) 治疗方案显示出类似于添加胰岛素的血糖控制. 三重OHA方法也改善了脂质配置文件,并减少了低血糖.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学 是一个学科.
背景情况:
- 二型糖尿病 (T2DM) 经常需要治疗强化超出最初的口服低血糖剂 (OHAs).
- 常见的策略包括升级到三重OHA疗法或将胰岛素添加到双重OHA组合中.
- 个性化治疗对于有效管理T2DM至关重要.
研究的目的:
- 为了比较添加第三个OHA与添加预混合胰岛素到双OHA (西塔格利普丁+美特福林) 治疗方案的疗效.
- 评估2型糖尿病患者的血糖控制,脂质概况,体重和低血糖发生率,这些患者的HbA1c水平不受控制.
主要方法:
- 一项前后研究设计,涉及80名T2DM患者,HbA1c>7%超过3个月.
- 患者被分为两组:第一组 (西塔格利普丁 + 甲胺 + 第三个OHA) 和第二组 (西塔格利普丁 + 甲胺 + 胰岛素70/30).
- 评估的参数包括HbA1c,血糖水平,脂质概况,体重和低血糖期.
主要成果:
- 两种疗法都实现了类似的血糖控制 (HbA1c:9.1%与9%,p=0.724).
- 三重OHA组的BMI,胆固醇和LDL显著改善 (分别p<0.001,p=0.023,p=0.003).
- 与胰岛素组 (47.5%,p=0.004) 相比,三重OHA组 (7.5%) 的低血糖发作显著减少.
结论:
- 三重OHA疗法在T2DM中显示出与胰岛素添加可比的血糖控制.
- 三重OHA疗法在改善BMI,脂质概况和显著降低低血糖症方面提供了额外的好处.
- 对于需要强化治疗的T2DM患者来说,三重OHA可能是最好的选择.
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