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在患有内出血的患者中,ABO相同与不相容的血小板输血
Lauren K Dunn1,2, Emily Venner1, Matthew Nguyen1
1Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, United States of America.
PloS one
|November 21, 2024
概括
在患有内出血 (ICH) 的患者中,ABO相同的血小板输血与ABO不兼容的输血一样有效. 这项研究发现,输血后血小板增加或输血类型之间的神经结果没有显著差异.
科学领域:
- 血液学 血液学 血液学
- 神经学 神经学
- 输血医学 输血医学
背景情况:
- 内出血 (ICH) 患者经常接受血小板输血以缓解出血.
- 假设ABO相同的血小板输血比ABO不兼容的更有效.
研究的目的:
- 在ICH患者中,比较ABO相同与ABO不相容的血小板输血的疗效.
- 为了评估输血后的血小板增加和神经学结果.
主要方法:
- 对167名成年ICH患者 (2018-2022) 的回顾性审查.
- 分层分为ABO相同,ABO主要不兼容和ABO小不兼容的输血组.
- 绝对血小板增加和临床结果的比较 (修改的兰金表,大脑性能类别).
主要成果:
- 在ABO相同和不相容的输血组之间,绝对血小板增加没有显著差异.
- 血小板的中位数增加:7x10^9/L (相同),10x10^9/L (主要不兼容),11x10^9/L (小不兼容).
- 在有利的神经学结果或具有良好的功能生存中没有显著差异.
结论:
- 与ABO相同和ABO不相容的血小板输血在ICH患者中表现出类似的疗效.
- 目前的数据不支持在这个人群中强制偏好ABO相同血小板.
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