患有多发性硬化症的人与健康相关的生活质量低下相关的因素:基于量子的细分方法
Stefania Iaquinto1, Benjamin Victor Ineichen2, Anke Salmen3
1Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
PloS one
|November 21, 2024
概括
多发性硬化症的症状负担,包括抑郁,软弱和疼痛,显著影响与健康相关的生活质量 (HRQoL). 管理这些症状对于改善多发性硬化症 (PwMS) 患者的治疗结果至关重要.
科学领域:
- 神经学 神经学
- 生活质量研究 研究 生命质量研究
- 康复医学 康复医学 康复医学
背景情况:
- 与健康相关的生活质量 (HRQoL) 是患有多发性硬化症 (MS) 患者的关键管理目标.
- 虽然年龄和疾病持续时间是已知的因素,但在患有MS (PwMS) 的人群中降低HRQoL的其他决定因素需要进一步调查.
研究的目的:
- 确定与减少HRQoL相关的特定多发性硬化症疾病特征和症状负担.
- 了解多发性硬化症病因和患者报告的结果之间的关系.
主要方法:
- 利用了来自1697年瑞士多发性硬化病登记处的数据.
- 采用经年龄和疾病持续时间调整的量子位回归来分析与低HRQoL相关的因素 (EQ-5D的第25百分位).
- 在HRQoL组中比较PwMS,使用社会人口统计学,症状负担,MS严重性得分 (MSSS) 和步行障碍.
主要成果:
- 在PwMS中,低HRQoL与获得残疾福利,抑郁症,肌肉衰弱,记忆问题,疼痛和严重的步行障碍有关.
- 更高的MS严重性得分 (MSSS) 与报告低HRQoL的可能性增加相关.
- 抑郁,疼痛和虚弱等关键症状成为减少HRQoL的重要预测因素.
结论:
- 症状负担和MS的整体严重程度是与MS患者的HRQoL较低相关的关键因素.
- 针对性地管理抑郁,疲劳,疼痛和肌肉虚弱等症状对于保持或增强HRQoL至关重要.
- 专注于症状管理的干预措施可以显著改善患有多发性硬化症的人的生活质量.
相关概念视频
01:21Dimensions of Health and Illness
7.1K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
7.1K
01:29Concepts of Health and Illness
14.2K
Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
14.2K
01:15Quartile
4.1K
Quartiles are numbers that separate the data into quarters. Quartiles may or may not be part of the data. To find the quartiles, first, find the median or second quartile. The first quartile, Q1, is the middle value of the lower half of the data, and the third quartile, Q3, is the middle value, or median, of the upper half of the data. To get the idea, consider the same data set:
1; 1; 2; 2; 4; 6; 6.8; 7.2; 8; 8.3; 9; 10; 10; 11.5
The median or second quartile is seven. The lower half of the...
1; 1; 2; 2; 4; 6; 6.8; 7.2; 8; 8.3; 9; 10; 10; 11.5
The median or second quartile is seven. The lower half of the...
4.1K
01:20Lifestyle Factors and Health
36
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
36
01:18Factors Affecting Illness
4.2K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.2K