多发性硬化症患者的缩模式与认知障碍,疲劳和情绪障碍
Carolina de Medeiros Rimkus1, Mariana Penteado Nucci1, Isabella B Avolio1
1From the Department of Radiology and Oncology (C.d.M.R., C.C.L.), Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP); LIM 44 (C.d.M.R., M.P.N., I.B.A., C.C.L.), Laboratory of Medical Investigation in Magnetic Resonance of the University of São Paulo, São Paulo, Brazil; MS Center Amsterdam (C.d.M.R., M.M.S.), Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, location VUmc, the Netherlands; Department of Neurology (S.L.A.-P., D.C.), Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP); Department of Epidemiology and Biostatistics (M.B.W.), Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS); Department of Epidemiology and Biostatistics (M.B.W.), School of Medicine, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Brazil; MS Center Amsterdam (F.B.), Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, location VUmc, the Netherlands; and Queen Square MS Center (F.B.), Department of Neuroinflammation, Institute of Neurology, Faculty of Brain Sciences, and Centre for Medical Image Computing (CMIC) (F.B.), Department of Medical Physics and Biomedical Engineering, University College London (UCL), United Kingdom.
多发性硬化症 (MS) 的认知障碍与深层灰质缩有关,而疲劳,焦虑和抑郁与小脑缩有关. 综合症状与增加的全球和深灰质缩相关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 认知障碍,疲劳和情绪障碍在多发性硬化症 (MS) 中很普遍.
- 在MS中这些症状的相互作用和神经基础尚未完全理解.
- 识别与这些症状相关的缩模式对于理解MS进展至关重要.
研究的目的:
- 在多发性硬化症 (MS) 患者中识别脑缩的特定模式.
- 在MS患者中调查认知障碍,疲劳,焦虑和抑郁之间的关系.
- 为了将这些症状与皮质和深灰质缩的明显模式相关联.
主要方法:
- 横截面队列研究,包括复发性复发性MS患者和健康对照.
- 利用认知评估,疲劳,焦虑和抑郁 inventories,以及扩展残疾状态量表 (EDSS).
- 采用K-means集群来对症状进行分组,FreeSurfer用于评估皮质,深灰质和缩.
主要成果:
- 根据认知状态和症状存在,确定了四个多发性硬化症患者群.
- 认知障碍与深层灰色物质缩相关 (海马体,杏仁体,丘陵体,基底腺节).
- 疲劳,焦虑和抑郁与小脑缩和广泛的皮质缩有关.
结论:
- 在MS中,认知障碍和情绪/疲劳症状可以独立发生或一起发生.
- 深灰质缩与认知障碍有关,小脑缩与疲劳,焦虑和抑郁有关.
- 这些症状的逐渐积累与MS中全球和深灰质缩的增加有关.
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