以正念为基础的生活方式干预痴呆症风险降低:我的健康大脑可行性随机对照试验的协议
Ryan A Mace1,2, Makenna E Law1, Joshua E Cohen1
1Center for Health Outcomes and Interdisciplinary Research (CHOIR), Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.
我的健康大脑 (MHB) 是一项基于正念的计划,有望改善阿尔茨海默病和相关痴呆症风险的老年人认知功能和生活方式行为.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 行为科学 行为科学
背景情况:
- 生活方式行为和正念积极影响认知功能,并可能预防阿尔茨海默病和阿尔茨海默病相关痴呆症 (AD/ADRD).
- 我的健康大脑 (MHB) 是一项基于正念的生活方式的新计划,旨在针对主观认知衰退的老年人,针对AD/ADRD风险因素.
- 试点研究 (NIH 阶段 1A) 表明 MHB 是可行的,可以接受的,并改善生活方式行为和认知结果.
研究的目的:
- 为了比较MHB的可行性与老年人 (≥60岁) 的健康增强计划 (HEP) 控制与主观认知衰退和ADRD风险因素的可行性.
- 评估可行性基准,认知和生活方式结果的改善,以及在NIH1B阶段随机对照试验 (RCT) 中假设机制的参与.
主要方法:
- 通过诊所,传单,网络平台和社区伙伴关系进行招聘.
- 随机对照试验 (RCT) 将8周的远程医疗小组提供MHB (正念和行为修改) 与HEP (生活方式教育和小组支持) 的比较.
- 主要结果包括可行性,可接受性,适当性,可信性,满意度和忠诚度;次要结果评估认知功能和生活方式行为 (身体活动,睡眠,营养,物质使用,社交活动).
主要成果:
- 招聘开始于2024年1月,有225个询问和40名符合条件的参与者 (17.8%).
- 21名参与者参加了两个队列;9人 (43%) 完成了MHB或HEP和干预后评估.
- 在可穿戴设备 (87.1%) 和日常调查 (86.1%) 中观察到高坚持率;没有注册参与者退出. 预计在2024年12月完成入学.
结论:
- 该RCT将为一个更大的有效性试验 (NIH第二阶段) 在一个多样化的样本中提供 MHB 的信息,检查理论驱动的调解者和改进的调节者.
- MHB对正念和生活方式行为改变的整合提供了一个潜在的有效和可持续的策略,以减少老年人患AD/ADRD的风险.
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