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循环体,酸盐和酸盐以及认知能力下降,结构性大脑异常和痴呆症的风险
Laia Gutierrez-Tordera1,2,3,4, Kristine F Moseholm4, Marta Trius-Soler4,5
1Nutrition and Metabolic Health Research Group, Department of Biochemistry and Biotechnology, Rovira iVirgili University (URV), 43201 Reus, Spain.
Aging and disease
|November 21, 2024
概括
老年人中较高的水平与更快的认知衰退和痴呆症死亡率有关. 相反,酸盐和酸盐与降低痴呆风险和减缓认知衰退有关.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 老年学是一门学科.
背景情况:
- 能量代谢和大脑健康之间的相互作用,特别是老年人群的认知功能和痴呆风险,仍然不完全理解.
- 研究循环能量代谢物提供了对神经退行过程的潜在见解.
研究的目的:
- 检查体 (乙酸盐,β-基酸盐,乙),酸盐和酸盐与老年人认知能力下降,大脑结构和痴呆风险的血水平之间的关联.
- 确定这些代谢物与长期随访期间痴呆相关死亡率之间的关系.
主要方法:
- 在心血管健康研究中,从1850名老年人的血样本中,使用核磁共振 (NMR) 分析了体,酸盐和酸盐.
- 认知能力下降的评估是使用经过修改的迷你精神状态检查和数字符号替代测试进行的,持续了9年.
- 使用考克斯回归,MRI和线性回归模型评估了痴呆发病率,痴呆相关死亡率,白质病变和心室大小.
主要成果:
- 血基水平升高,特别是β-基酸盐,与加速的认知衰退和与痴呆相关的死亡率增加相关.
- 较高度的pyruvate与较慢的认知衰退,心室尺寸减少,以及较低的痴呆风险和死亡率有关.
- 酸盐含量增加与较少的认知衰退和痴呆症风险降低有关.
结论:
- 在65岁及以上的个体中,循环体与不良的认知结果和更高的痴呆症死亡率有关.
- 相反,酸盐和酸盐表现出一种保护性关联,与较低的痴呆风险和较慢的认知衰退相关,突出了它们在维持大脑健康方面的潜在作用.
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