和聚乙烯化物微塑料在子脏中在氧化应激下诱导线粒体损伤和亡
Hui Zou1, Jie Song2, Xianzu Luo2
1College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, PR China; Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu 225009, PR China; Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu 225009, PR China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, PR China.
聚乙烯微塑料和暴露会损害莫斯科的脏,导致氧化应激和亡. 联合暴露减少了的积累,并通过激活Nrf2通路来减轻了一些毒性作用.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 水生毒理学 水生毒理学
背景情况:
- 聚乙烯微塑料 (PVC-MPs) 和 (Cd) 是普遍存在的水污染物.
- 莫斯科,作为水禽,与陆地家禽相比,对PVC-MPs和Cd毒性的敏感性更高.
- 了解PVC-MPs和Cd对水禽脏健康的联合毒理影响至关重要.
研究的目的:
- 研究PVC-MPs和Cd对莫斯科的脏的单独和联合作用.
- 阐明毒性的潜在机制,包括氧化应激,元素代谢,线粒体功能和亡.
主要方法:
- 莫斯科暴露在10毫克/升的PVC-MP和50毫克/公斤的Cd中,单独或组合.
- 分析了脏重量,生化参数 (肌素,尿素),氧化应激标志物,宏观/微量元素水平和线粒体蛋白质表达.
- 评估了与亡相关的蛋白质,基因表达和TUNEL染色,以评估细胞死亡.
主要成果:
- 无论是PVC-MP还是单独使用Cd,都会影响功能,破坏氧化平衡,改变元素代谢.
- 联合PVC-MPs+Cd暴露减少了Cd在脏中的积累,并减轻了线粒体损伤.
- 通过联合暴露激活了Nrf2信号通路,从而恢复了抗氧化蛋白和减少了亡.
结论:
- 和PVC-MPs通过氧化应激,元素代谢失调,线粒体功能障碍和亡诱导损伤.
- 对PVC-MPs和Cd的联合暴露表明了复杂的相互作用,可能会对Cd积累和毒性产生一些保护作用.
- Nrf2通路在排毒和减轻这些污染物引起的氧化应激中发挥着重要作用.
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