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Updated: Jun 7, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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甲基RNA m6在肉的LPS激活Kupffer细胞中的葡萄糖皮质体受体的A介导的转录后抑制

Yulan Zhao1, Yidan Jiang1, Yue Feng1

  • 1MOE Joint International Research Laboratory of Animal Health and Food Safety, Nanjing Agricultural University, Nanjing, Jiangsu, PR China; Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, PR China.

Poultry science
|November 21, 2024
PubMed
概括

在免疫激活过程中,m6ARNA甲基化调节葡萄糖皮质体受体 (GR). 这项研究揭示了m6A修饰会损害GR mRNA的稳定性,降低蛋白质水平,为肝炎提供新的表观遗传治疗点.

关键词:
这是一个很大的问题.巨细胞,RNA m(6) 一种甲基化,免疫激活,转录后调节.

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
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