通过胆汁提取减轻人类肝胆器官中聚乙烯微塑料诱导的肝毒性
Peilin Li1, Daisuke Miyamoto2, Tomohiko Adachi2
1Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8102, Japan; Department of Surgery, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.
Ecotoxicology and environmental safety
|November 21, 2024
概括
聚烯微塑料 (PS-MPs) 在肝脏中积累,造成损伤并改变胆酸代谢. 乌尔索多西胆酸促进PS-MP的积累,而格利塔则抑制了它,提供了潜在的治疗见解.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 聚烯微塑料 (PS-MPs) 是无处不在的环境污染物.
- 摄入PS-MP和生物积累可能导致人体器官损伤,特别是肝脏损伤.
- PS-MPs对人类肝毒性的确切影响及其代谢命运在很大程度上是未知的.
- 新出现的证据表明PS-MPs会破坏脂质和胆酸代谢.
研究的目的:
- 研究PS-MP生物积累对人类肝毒性的影响.
- 为了阐明PS-MPs在肝脏中的代谢途径.
- 探索潜在的治疗策略,以减轻PS-MP诱导的肝损伤.
主要方法:
- 利用人类肝胆器官 (HBOs) 作为肝脏疾病和新陈代谢的生物工程模型.
- 暴露HBOs到1微米PS-MPs48小时.
- 研究了胆汁载体 (BSEP,MRP-2) 和它们的调节剂 (ursodeoxycholic acid,troglitazone) 在PS-MP积累和毒性的作用.
主要成果:
- 在HBOs中,PS-MP暴露诱导了肝毒性,肝细胞损伤和改变胆酸代谢.
- 在HBOs的胆道内积累的PS-MPs.
- 乌尔索西胆酸通过激活BSEP和MRP-2增强了PS-MP的积累和胆汁流动.
- 胆汁载体抑制剂格利塔阻断了PS-MP的积累,但加剧了PS-MP诱导的肝毒性.
结论:
- 这项研究阐明了使用HBOs在肝脏中PS-MP积累和毒性的机制.
- 这些发现凸显了胆汁载体在PS-MP肝部处置中的关键作用.
- 该研究表明,调节胆汁载体活性可能是PS-MP诱导的肝损伤的潜在治疗策略.
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