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Updated: Jun 7, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Published on: August 5, 2022

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尼古丁胺衍生物作为DNA脱甲基酶ALKBH2抑制剂的发现和结构-活性关系研究

Ke Xu1, Feng Li2, Liang Xiong2

  • 1Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, China.

European journal of medicinal chemistry
|November 21, 2024
PubMed
概括

研究人员开发了AH2-14c,这是第一个针对AlkB同源2 (ALKBH2) DNA脱甲基酶的强效和选择性抑制剂. 这种化合物对质母细胞瘤治疗和进一步研究ALKBH2具有前景.

关键词:
这就是ALKBH2H2的意思.质母细胞瘤 (glioblastoma) 是一个N(3) - 甲基细胞氨酸.小分子抑制剂小分子抑制剂结构与活动的关系.

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