评估皮下脂肪组织厚度作为宫椎间盘退化的生物标志物
1University of Health Sciences, Umraniye Training and Research Hospital, Department of Radiology, Istanbul, Turkey.
概括
皮下脂肪组织厚度增加 (SFTT) 与中年妇女的椎椎间盘退化 (IVDD) 有关. 更高的SFTT,特别是在C7级,可能表明患IVDD的风险更高.
科学领域:
- 整形外科 整形外科 整形外科
- 放射学 放射学是一门学科.
- 肌肉骨系统疾病 肌肉骨系统疾病
背景情况:
- 椎间盘退化 (IVDD) 导致部疼痛,并与机械不稳定性有关.
- 肥胖和皮下脂肪组织厚度增加 (SFTT) 是IVDD的确定的危险因素.
研究的目的:
- 调查SFTT与宫IVDD的存在/严重程度之间的相关性.
- 评估SFTT作为IVDD潜在的非侵入性生物标志物.
主要方法:
- 对245名患有部疼痛的女性 (40-50岁) 进行了回顾性分析,接受了宫MRI.
- 使用Pfirrmann系统和SFTT测量在T2加权MRI上的IVDD分级在C3,C5和C7水平.
- 包括曼-惠特尼U,克鲁斯卡尔-瓦利斯,斯皮尔曼相关性和ROC分析在内的统计分析.
主要成果:
- 在所有测量的宫水平上,在较高的SFTT和IVDD的存在/严重程度之间发现了显著的正相关性 (p < 0.001).
- 在C7的SFTT切线为22.57毫米,对IVDD显示了79.19%的灵敏度和63.89%的特异性.
- 2级IVDD是患有退化症的参与者中最常见的发现.
结论:
- 增加的SFTT与中年妇女的宫IVDD有关.
- 特别是C7级的SFTT可以作为IVDD的有用的非侵入性生物标志物.
- 建议进行进一步的多中心研究来验证这些发现.
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