脊髓刺激对后神经疼痛的长期影响
Egor D Anisimov1, Oleg M Andrushkevich1, Vidzhai M Dzhafarov2
1Federal Neurosurgical Center, Ministry of Health of Russia, Novosibirsk, Russian Federation.
Stereotactic and functional neurosurgery
|November 21, 2024
概括
脊髓刺激 (SCS) 在试验期间有效治疗了50%的耐药性后神经疼痛 (PHN) 患者. 长期随访显示,植入SCS系统的患者显著减少疼痛,改善生活质量.
科学领域:
- 神经学 神经学
- 疼痛管理 疼痛管理
- 神经外科 神经外科
背景情况:
- 末神经疼痛 (PHN) 是一种严重的疼痛综合征,在疹爆发后发生.
- 耐药性影响超过50%的PHN患者,需要替代治疗.
- 神经调节,包括脊髓刺激 (SCS),是耐火PHN的最后手段.
研究的目的:
- 评估脊髓刺激 (SCS) 在患有慢性耐药性脊髓后神经疼痛 (PHN) 患者的疗效.
- 评估SCS植入PHN后的长期结果,包括疼痛减轻和生活质量.
主要方法:
- 在32名患有慢性耐药PHN的患者中进行了SCS试验.
- 成功试验的患者继续进行永久的SCS植入,结果通过VAS,SF-36,PGIC和MQS进行评估.
- 没有通过试验的患者的对照组被监测疼痛水平.
主要成果:
- 在试验阶段,Tonic SCS在50% (16/32) 的患者中有效.
- 在14名植入患者中,71.4% (10/14) 经历了显著的疼痛减轻 (>50%与基线相比).
- 与保守治疗相比,SCS患者的疼痛水平在统计上较低,SF-36,PGIC和MQS得分有所改善.
结论:
- 在接受SCS试验的耐火PHN患者中,Tonic SCS在50%的患者有效.
- 长期的SCS治疗显著改善了疼痛控制,提高了生活质量,并减少了PHN患者的止痛药物需求.
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