相关实验视频

Updated: Jul 6, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

作为甲状腺癌的潜在诊断标记物,CALML6通过调节免疫微环境来促进甲状腺癌细胞的增殖

Caixia Cheng¹, Weiwei Shi², Songrui Zhang¹

¹Department of Pathology, The First Hospital, Shanxi Medical University. Taiyuan, Shanxi, China.

|November 21, 2024

概括

卡尔莫杜林类6 (CALML6) 表达在乳头甲状腺癌 (PTC) 中降低,并与晚期疾病有关. CALML6可以作为PTC的诊断标记物和免疫治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

卡尔莫杜林类6 (CALML6) 是一种与炎症相关的基因.
它的表达模式可能与各种癌症类型有关.

研究的目的:

研究CALML6表达在乳头甲状腺癌 (PTC) 中的作用和意义.
确定CALML6表达是否与甲状腺癌的临床病理特征和患者结局相关.

主要方法:

使用了癌症基因组图谱 (TCGA),基因型组织表达项目 (GTEx) 和UALCAN数据库.
在甲状腺癌组织上进行了免疫组织化学测定.
使用RNA干扰 (RNAi) 来研究PTC细胞中的CALML6功能.

主要成果:

与正常组织相比,甲状腺癌组织中的CALML6表达被发现较低.
减少CALML6表达与甲状腺外延伸,淋巴结转移,先进的病理T阶段和甲状腺癌高细胞亚型相关.
通过RNAi敲除CALML6,显著抑制了PTC细胞生长,并诱导了细胞循环停止.
在甲状腺癌组织中通过免疫组织化学观察到CALML6的升级.
CALML6的表达与免疫检查点基因CD274和PDCD1LG2.2有关.

结论:

CALML6可能作为PTC的新型诊断生物标志物发挥作用.
CALML6的表达与PTC的侵入性和高细胞亚型密切相关.
在PTC中,CALML6是免疫治疗的潜在治疗标.

更多相关视频

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

相关概念视频

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...