沈陵百祖圣通过SIRT1-PGC-1α介导的线粒体生物发生来缓解中心疲劳
Ruochong Wang1, Yan Liu1, Yang Jiang1
1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.
Journal of ethnopharmacology
|November 21, 2024
概括
沈陵百祖圣 (SLBZS) 通过增强线粒体功能和激活SIRT1/PGC-1α通路,有效治疗中枢疲劳 (CF). 这种传统中医药配方对管理疲劳症状和改善整体幸福感有很大的前景.
科学领域:
- 药理学 药理学是指药理学的学科.
- 线粒体生物学 线粒体生物学
- 传统中国医药 传统中国医药
背景情况:
- 沈陵百祖圣 (SLBZS) 是一种传统中医 (TCM) 配方,历来用于治疗疲劳.
- 中心疲劳 (CF) 与TCM中欠缺有关.
- 对SLBZS对CF的影响及其机制的研究是有限的.
研究的目的:
- 评估SLBZS在治疗通过修改多平台方法 (MMPM) 诱导的CF中的疗效.
- 调查潜在的机制,重点关注线粒体生物发生和SIRT1/PGC-1α通路.
主要方法:
- 通过睡眠剥夺在老鼠中诱导CF.
- 在不同剂量中,SLBZS被施用.
- 使用LC-MS/MS分析了SLBZS的化学成分.
- 对海马和血清样本进行了行为,生化和分子分析.
主要成果:
- 在CF大鼠中,SLBZS改善了身体表现,情绪状态和认知功能.
- SLBZS增加了血清ATP,减少了疲劳标志物,并逆转了线粒体损伤.
- 在海马体中,SLBZS上调SIRT1/PGC-1α通路的表达.
结论:
- SLBZS有效地缓解了CF的症状.
- SLBZS通过上调SIRT1/PGC-1α通路来增强线粒体功能.
- SLBZS提出了一个潜在的治疗策略来管理中心疲劳.
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