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饮食模式,唾液DNA甲基化和肺部健康:曾经吸烟过的人的流行病学研究
Yue Feng1, Huining Kang2, Akshay Sood3
1Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM.
Chest
|November 21, 2024
概括
一种新的饮食模式,DiPHeaL,有利于肺部健康,特别是在前吸烟者身上. 这种富含蔬菜和茶叶的模式可能会降低死亡率和疾病风险.
科学领域:
- 肺部医学 肺部医学
- 营养科学 营养科学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 唾液中的12个基因甲基化面板预测了肺老化和癌症风险.
- 这个小组作为对肺部健康饮食模式的读数的潜力尚未被探索.
研究的目的:
- 使用唾液甲基化数据来推导一种饮食模式.
- 评估这种模式与肺部健康和死亡率的关联.
- 根据吸烟状况调查这些关联的变化.
主要方法:
- 使用了洛维莱斯吸烟者队列 (LSC) 和前列腺,肺部,结肠直肠和卵巢 (PLCO) 癌症查试验.
- 采用最小绝对收缩和选择操作员 (LASSO) 回归来定义饮食模式.
- 使用通用线性和考克斯模型检查了与肺功能,生活质量和死亡率的关联.
主要成果:
- 健康肺部的饮食模式 (DiPHeaL) 强调深绿色蔬菜,茶,酒精和果汁,低加工肉类摄入量.
- 在前吸烟者中,较高的DiPHeaL得分与改善的肺功能 (FEV1,FEV1/FVC),呼吸道生活质量和心肺死亡率的降低相关.
- 这些好处在呼吸道阻塞的前吸烟者中更为明显,并在PLCO试验中得到重复.
- 在PLCO试验中,DiPHeaL与前吸烟者肺癌发病率降低有关,并减少了COPD发病率和肺癌死亡率.
结论:
- 发现了一种与肺部表观遗传衰老相关的新型饮食模式 (DiPHeaL).
- 通过DiPHeaL进行营养修改可能对前吸烟者,特别是那些有呼吸道阻塞的人有显著的益处.
- 这种饮食模式显示出改善肺部健康结果和降低疾病风险的前景.
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