泰国红树林Xylocarpus moluccensis中发现的十种林类动物和三个原始林类动物
Li-Fu Liu1, Wei Zhao1, Patchara Pedpradab2
1Guangdong Key Laboratory for Research and Development of Natural Drugs, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan 523808, China; College of Pharmacy, Jinan University, #855Xingye Avenue, Guangzhou 510632, China.
Fitoterapia
|November 21, 2024
概括
在Xylocarpus moluccensis种子中分离出了12种新的limonoid和protolimonoid. 一些化合物,包括西洛莫隆F,M和P,在基于细胞的测试中显示出中度的氧化抑制活性.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 红树林植物化学 红树林植物化学
背景情况:
- 红树林Xylocarpus moluccensis是一种丰富的生物活性二次代谢物的来源.
- 类和原类是众所周知的各种药理活动的化合物类别.
研究的目的:
- 从Xylocarpus moluccensis的种子中分离和描述新型的类和原类化合物.
- 调查分离化合物的潜在生物活性,特别是它们的氧化抑制作用.
主要方法:
- 使用色谱技术分离化合物.
- 通过综合光谱分析 (NMR,X射线衍射,ECD) 阐明结构.
- 在脂聚糖诱导的RAW 264.7细胞中检测氧化生产抑制的生物试验.
主要成果:
- 确定了10种新的林蒙类 (xylomolones E-N) 和2种新的原始林蒙类 (xylomolones O-P).
- 通过NMR,X射线衍射和ECD光谱学证实了结构.
- 克西洛摩隆F,M和P表现出中度的氧化抑制活性,IC50值在22.7至62.84μM之间.
结论:
- 这项研究扩大了Xylocarpus moluccensis. limonoids和protolimonoids的化学多样性.
- 已识别的化合物,特别是西洛莫隆F,M和P,代表了开发抗炎药物的潜在线索.
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