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血液DNA甲基化,饮食质量指数和代谢健康之间的关系:来自Obekit研究的数据

Aline Rosignoli da Conceição¹, Josefina Bressan¹, Marta Cuervo²

¹Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Brazil.

The Journal of nutritional biochemistry

|November 21, 2024

概括

饮食质量和特定的营养素影响DNA甲基化 (DNAm),影响代谢健康. 超加工食品 (UPF) 和健康的植物性饮食 (hPDI) 最好预测西班牙成年人的心脏代谢风险因素.

科学领域:

营养上的表观遗传学
代谢健康研究研究
人类遗传学人类遗传学

背景情况:

疾病易感性的个体间差异可能涉及表观遗传机制.
饮食因素是已知的表观遗传过程的调节者.
了解饮食,表观遗传学和代谢健康之间的相互作用至关重要.

研究的目的:

在西班牙人口中调查DNA甲基化 (DNAm),饮食质量和代谢健康之间的关联.
为了确定特定的饮食成分和与DNAm模式相关的索引.
探索饮食质量指数对心脏代谢风险因素的预测价值.

主要方法:

对337名西班牙参与者的横截面研究 (Obekit研究).
通过食物频率问卷和建立得分 (PDI,hPDI,UPDI,DDS,MPF,UPF,MD) 来评估饮食质量.
在白细胞中使用Infinium MethylationEPIC v1.0 BeadChip套件分析DNA甲基化,重点关注5261个CpG位点.

主要成果:

在营养素和CpG位点之间发现了四个显著的相关性 (例如,酒精与GLUD1,叶酸,与PAPSS2,鱼类与SLC7A6).
在ZFP57中,差异甲基化区域 (DMR) 与肥胖,营养和饮食质量指数有关.
超加工食品 (UPF) 和健康植物性饮食指数 (hPDI) 显示,对心脏代谢风险因素的预测值最强.

结论:

特定的营养素和饮食质量指数,特别是UPF和hPDI,似乎会影响DNA甲基化模式.
这些表观遗传修饰可能在决定西班牙人口代谢健康结果方面发挥作用.
这些发现突显了针对表观遗传修饰的饮食干预措施的潜力,以改善代谢健康.

关键词:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.地中海饮食地中海饮食肥胖问题肥胖问题植物性饮食是一种植物性饮食.预测模型是一个预测模型.超加工食品超加工食品超加工食品

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