用乳清蛋白粉进行12个月的干预对轻度认知障碍的老年人认知功能的影响:随机对照试验
Fengping Li1, Ruikun He2, Zhongbao Yue2
1Department of Food and Nutrition Health, School of Public Health, Wuhan University, Wuhan, China; Department of Clinical Nutrition, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
The American journal of clinical nutrition
|November 21, 2024
概括
乳清蛋白粉补充剂改善了轻度认知障碍 (MCI) 患者的认知功能. 这项为期12个月的研究发现了对全球认知和特定认知领域的显著益处.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 以前的动物研究表明,牛奶脂肪球体膜 (MFGM) 可以缓解阿尔茨海默病的病理.
- 形成了一个假设, whey蛋白,富含MFGM,牛素和B族维生素,可以增强轻度认知障碍 (MCI) 患者的认知功能.
研究的目的:
- 研究乳清蛋白粉补充剂对被诊断患有MCI的老年人认知功能的12个月效果.
- 评估乳清蛋白对全球认知功能和二级认知领域的影响.
主要方法:
- 一个为期12个月的随机对照试验,涉及107名患有MCI的参与者.
- 参与者被随机分配,接受每天15克乳清蛋白粉或安慰剂.
- 用蒙特利尔认知评估 (MoCA) 和其他测试在基线,6个月和12个月评估认知功能.
主要成果:
- 与安慰剂组相比,乳清蛋白组的MoCA得分明显改善 (1.81差异,P<0.05).
- 在二次认知结果中也观察到显著的好处,包括数字符号替代测试.
- 该干预措施被很好地容忍,报告的副作用在两组之间没有显著差异.
结论:
- 补充12个月富含MFGM,牛素和B族维生素的乳清蛋白粉,可证明改善了MCI老年人的认知功能.
- 这表明乳清蛋白是一种潜在的营养策略,用于管理这一群体的认知衰退.
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