在癌症中,ABC蛋白与多药耐药性的关联
Andrezza Viviany Lourenço Marques1, Bruna Estelita Ruginsk1, Larissa de Oliveira Prado1
1Graduate Program in Pharmaceutical Sciences, Laboratory of Cancer Drug Resistance, Federal University of Parana, Curitiba, Paraná, Brazil.
Biochimica et biophysica acta. Molecular cell research
|November 21, 2024
概括
癌症中的多药性耐药性 (MDR) 通常是由ATP结合盒 (ABC) 蛋白质引起的. 这次审查将20种ABC蛋白与MDR联系起来,有助于新的治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多药耐药性 (MDR) 是癌症治疗的一个主要障碍,特别是转移性癌症.
- 过度表达ATP结合盒 (ABC) 蛋白质是导致MDR的一个关键机制.
研究的目的:
- 审查并确定ABC蛋白过度表达和癌症中MDR之间的相关性.
- 为了确定特定的ABC蛋白及其相关的抗癌药物参与MDR.
主要方法:
- 在体外和临床研究的文献综述.
- 概述ABC蛋白质的七个子家族及其定位.
- 鉴定了与MDR相关的20种ABC蛋白和29种药物作为关键载体的基质.
主要成果:
- 有20种ABC蛋白 (ABCA1-3,ABCA7,ABCB1-2,ABCB4-6,ABCC1-5,ABCC10-11,ABCE1,ABCF2,ABCG1,ABCG2) 与MDR有关,这些蛋白质可以与MDR相关联.
- 29种抗癌药物是ABCB1,ABCC1或ABCG2.2的基质.
- 通常用于乳腺癌,肺癌和白血病的化疗药物受到ABC载体介导的MDR的影响.
结论:
- 在各种癌症中,ABC蛋白在MDR中发挥着关键作用.
- 了解ABC输送器功能对于开发有效的癌症治疗非常重要.
- 向ABC蛋白可能会提高治疗效率并改善患者的治疗结果.
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