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婴儿饮食中的有机阻燃剂来自北京,中国:检测和风险评估

Xiaohui Li¹, Lei Zhang², Xin Zhang³

¹Beijing Laboratory of Food Quality and Safety, Department of Nutrition and Health, China Agricultural University, Beijing, 100091, China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Control and Prevention, Beijing, 100013, China.

|November 21, 2024

概括

在婴儿配方奶粉和母乳中发现有机酸 (OPEs) 和其代谢物 (di-OPEs). 母乳给婴儿带来了更高的风险,因为有机酸盐二体的显著暴露.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
儿童营养学儿童营养学

背景情况:

有机酸 (OPE) 是常见的阻燃剂,在环境和人体样本中检测到.
关于哺乳期婴儿通过饮食接触OPE的数据有限.
有机酸二 (di-OPEs) 是OPEs的代谢产物.

研究的目的:

在北京,量化婴儿配方奶粉和母乳中的OPEs和di-OPEs.
为了估计哺乳婴儿的OPE和di-OPE饮食摄入量.
评估与婴儿配方奶粉和母乳相关的暴露风险.

主要方法:

在110个婴儿配方奶粉和122个母乳样本中分析了38个OPE和10个di-OPE.
气色谱-质谱 (GC-MS) 或液色谱-质谱 (LC-MS) 技术可能被用于检测.
根据检测到的度和婴儿平均摄入量计算估计的每日摄入量 (EDI).

主要成果:

在婴儿配方中经常检测到20个OPE和6个di-OPE;在母乳中检测到5个OPE和3个di-OPE.
从婴儿配方奶粉中估计每天摄入的OPE与母乳中的每日摄入量相当.
估计每天从母乳中摄取的二OPE的摄入量明显高于婴儿配方奶粉.

结论:

母乳是婴儿有机酸盐体暴露的重要来源.
婴儿配方奶粉也会导致有机酸和酸的暴露.
需要进一步的研究来了解di-OPEs的发育毒性.

关键词:

母乳是母乳中的一种.早期暴露的早期暴露.婴儿配方奶粉的使用方法有机酸二 Ester (di-OPEs) 是一种有机酸二.有机酸盐 (OPEs) 是一种有机酸盐.

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