在成人牛皮关节炎的管理方面取得了进展
Fadi Kharouf1,2, Dafna D Gladman3,2
1University of Toronto, Psoriatic Arthritis Program, University Health Network, Toronto Western Hospital, Toronto, ON, Canada.
概括
牛皮关节炎的治疗包括评估皮肤,关节和并发症. 本综述涵盖评估工具,非药物疗法和药理疗法,如传统和生物疾病修饰性抗风湿药物 (DMARDs).
科学领域:
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
- 内部医学 内部医学
背景情况:
- 牛皮关节炎 (PsA) 影响30%的牛皮患者,呈现出各种肌肉骨和皮肤问题.
- 由于伴随性疾病,如心血管疾病,糖尿病,代谢综合征,痛风,焦虑和抑郁症等,PsA的管理变得复杂.
- 有效的PsA护理需要对皮肤,关节和并发性疾病的综合评估.
研究的目的:
- 审查 psoriatic 关节炎评估的评估工具和结果措施.
- 总结治疗方法,包括非药物和药物干预措施.
- 讨论目前和新兴的病变修饰性抗风湿药物 (DMARDs) 治疗PsA.
主要方法:
- 对形关节炎的评估工具,结果措施和治疗策略的文献综述.
- 对非医疗干预 (教育,生活方式,物理治疗,职业治疗) 的证据综合.
- 对药理疗法的审查,包括NSAIDs,传统合成DMARDs,生物DMARDs (抗TNFα,抗IL-17,抗IL-12/23,抗IL-23),JAK抑制剂和PDE4抗剂.
主要成果:
- PsA评估需要对皮肤,关节和并发症进行评估.
- 治疗策略包括非药物选择和广泛的药物药剂.
- 目前的治疗方法包括传统的合成DMARDs,向的生物DMARDs,JAK抑制剂和PDE4抗剂.
结论:
- 个性化的牛皮关节炎治疗需要根据临床概况进行量身定制的药物选择.
- 生物标志物是需要预测治疗反应,并使更个性化的治疗方法.
- 针对肌肉骨,皮肤和并发症方面的综合管理对于最佳的PsA结果至关重要.
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