心肌性能指数用于评估自身免疫结缔组织疾病中的心脏功能:系统性审查和元分析
Rudy Hidayat1,2, Sally Aman Nasution3, Faisal Parlindungan4,2
1Rheumatology Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia.
Lupus science & medicine
|November 21, 2024
概括
这项研究发现,在患有自身免疫结缔组织疾病 (ACTD) 的患者中,心肌功能指数 (MPI) 升高. 在这些患者中,MPI可能有助于早期发现心脏功能障碍.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 自身免疫性结缔组织疾病 (ACTD) 可以影响心脏功能.
- 在ACTD患者中早期发现心脏异常对于管理至关重要.
- 心肌性能指数 (MPI) 是一个潜在的心声学标志物,用于心脏功能.
研究的目的:
- 在没有明显心血管异常的ACTD患者中使用MPI评估心脏功能.
- 在各种ACTD中系统地审查和元分析评估MPI的研究.
- 为了确定与健康对照组相比,ACTD患者的MPI是否升高.
主要方法:
- 在Medline,谷歌学者,Scopus和科克兰图书馆 (1995-2023) 的系统文献搜索.
- 包括ACTD:类风湿性关节炎,全身性硬化症,全身性红斑狼,Sjögren综合征.
- 在使用纽卡斯尔-太华尺度进行质量评估后,使用审查经理V.5.4对MPI的元分析.
主要成果:
- 包括22项研究 (19项用于定量合成),涵盖RA,SSc,SLE,SjD和混合结合组织疾病.
- 传统和组织多普勒成像 (TDI) MPI值在ACTD患者和对照患者中显著升高.
- 对于传统 (MD=0.11) 和TDI MPI (MD=0.06) 两种,p < 0.00001.
结论:
- 与健康个体相比,患有ACTD的患者表现出较高的MPI值.
- 在ACTD中,MPI显示了早期发现和治疗心脏功能障碍的潜力.
- 需要进一步的研究来证实这些发现及其临床影响.
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