相关实验视频
Updated: Jun 6, 2025

06:41
Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
12.4K
在患有脏功能障碍的儿童接受ECMO治疗时减少万科米辛剂量
Alexej Bobrowski1, René Höhn1, Rouven Kubicki1
1Department of Congenital Heart Defects and Pediatric Cardiology, University Heart Center Freiburg - Bad Krozingen, Medical Center - University of Freiburg, Freiburg, Baden-Württemberg, Germany.
The Thoracic and cardiovascular surgeon
|November 21, 2024
概括
对于患有功能受损的身体外膜氧化 (ECMO) 的儿童,需要较低的万科米辛剂量. 建议对这些儿科患者进行早期治疗药物监测,以优化万科米辛治疗.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 药理动力学和药理动力学
- 传染病管理 传染病管理
背景情况:
- 身体外膜氧化 (ECMO) 显著改变了药物的药理动力学.
- 在接受ECMO的儿科患者中,需要仔细考虑万科米辛的剂量.
- 有限的数据存在于ECMO上儿童的特定万科米辛剂量调整.
研究的目的:
- 为了比较ECMO治疗的儿科患者和非ECMO治疗的重症患者的万科米辛药理学.
- 确定适合接受ECMO的儿童的万科米辛剂量调整.
- 评估功能对ECMO患者万科米辛剂量的影响.
主要方法:
- 对心脏重症监护病房的儿科患者进行了回顾性队列研究.
- ECMO支持组与非ECMO控制组之间的比较 (延迟关闭).
- 分析了与体重 (mg/kg/d) 相比的万科米辛的最低水平和每日剂量.
主要成果:
- 与非ECMO患者 (38.5 mg/kg/d) 相比,ECMO患者每天接受的万科米辛剂量 (33.3 mg/kg/d) 显著较低.
- 两组人群的万科米辛血清最低水平相似,在目标范围 (10-20微克/毫升) 之内.
- 在ECMO患者中,治疗开始时功能受损的患者需要更低的万科米辛剂量 (22.5 mg/kg/d与42.1 mg/kg/d对比).
结论:
- 患有初始功能障碍的ECMO儿科患者需要较低的万科米辛剂量.
- 在ECMO患者中,应在早期开始对万科米的治疗药物监测,甚至在达到稳定状态之前.
- 对于儿科ECMO患者,特别是患有功能障碍的儿科ECMO患者,万科米辛的剂量方案可能需要调整.
相关概念视频
Renal Failure: Dose Adjustments
64
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
64
Factors Affecting Drug Response: Overview
1.9K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.9K
Drug Dosage Regimen: Overview
3.5K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
3.5K
Factors Affecting Renal Clearance: Renal Impairment
54
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
54
Rational Dosage Regimen: Maintenance Dose and Loading Dose
3.9K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
3.9K

