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重新分类cT4b口腔粘膜/牙口腔复杂癌症:我们需要改变吗?

Rakesh Katna¹, Aastha Maini², Parth Patni²

¹Jaslok Hospital and Research Centre, Pedder Road, Mumbai, India; Bombay Hospital and Research Centre, Marine Lines, Mumbai, India; Vedant Hospital, Thane, India.

The British journal of oral & maxillofacial surgery

|November 21, 2024

概括

对非常局部发达的口腔癌 (cT4b) 的手术是可行的. 这项研究显示了接受的瘤结局,包括生存率,对于接受手术切除的患者,即使有广泛的瘤参与.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
头部和部癌症头部和部癌症

背景情况:

T4b口腔癌是局部发达的,通常被认为是边界切除或不可切除的.
对这些晚期瘤的外科干预的作用仍然不完全定义.

研究的目的:

重新评估临床阶段T4b口腔癌的手术切除的可行性和瘤结果.
为了确定影响这种患者队列生存的预后因素.

主要方法:

在2013年至2021年期间接受治疗的218名cT4b口腔癌患者的回顾性评估.
患者接受了复合切除,有或没有新辅助化疗,以及选择性下腔 (ITF) 清除晚期疾病.
分析了瘤学结果和预后因素.

主要成果:

随访时间中位数为54个月,五年生存率为54% (局部区域对照),52% (无病生存率) 和59% (总生存率).
多变量分析确定结节疾病,围神经侵入和骨干干扰是整体生存的显著负面预后因素.
手术是可行的,尽管疾病已晚期,但结果是可以接受的.

结论:

对cT4b口腔癌的手术切除是一种可行的治疗选择.
仔细选择患者和手术技术,包括潜在的ITF清除,可以导致可接受的瘤结果.
节点状况,围神经侵入和骨参与是生存的关键预后指标.

关键词:

获得ITF的许可证.在T4b中,它是T4b.在口腔癌,口腔癌.

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