妇女的骨折历史与第一次发作或持久性厌食症神经疾病的妇女
Mariana P Lopes1,2, Sana Ahmed3,4, Lily Beaman5
1Department of Psychological Medicine, Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
概括
患有神经性厌食症 (AN) 的女性,即使在早期阶段,骨折的风险也显著增加. 这凸显了对AN患者早期骨健康查和讨论的需要.
科学领域:
- 骨健康和骨质疏松症研究
- 饮食障碍和心理健康问题
背景情况:
- 神经性厌食症 (AN) 与严重的健康并发症有关,包括骨密度下降.
- 在不同持续时间的AN女性中,骨折风险尚未完全理解.
研究的目的:
- 为了比较女性的骨折史,第一次发生AN (FE-AN) 和持久AN (P-AN) 与健康对照 (HC).
- 确定与P-AN骨折发生相关的因素.
主要方法:
- 119名女性 (49名FE-AN,46名P-AN,24名HC) 填写了在线调查问卷.
- 收集的数据包括饮食障碍症状,月经史和骨折史.
主要成果:
- 与HC (4.2%) 相比,FE-AN (33.3%) 和P-AN (37.8%) 组的骨折史显著更高.
- P-AN参与者比HC报告骨折的可能性高13.4倍,FE-AN参与者比HC报告骨折的可能性高10.3倍.
- 在P-AN中,更高的BMI,更短的缺血和怀孕史与较少的骨折有关.
结论:
- 即使在AN的早期阶段,骨折风险也会增加.
- 目前对AN骨查的指导方针可能需要修订.
- 关于骨健康风险的早期对话对AN患者,临床医生和护理人员至关重要.
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