血清骨循环标记与晚期青春期前期和早期青春期的骨质量有关
Jakob Rempe1,2, Björn E Rosengren2,3, Lars Jehpsson2,3
1Department of Orthopaedics, Helsingborg Hospital, Lund University, Helsingborg, Sweden.
Acta paediatrica (Oslo, Norway : 1992)
|November 21, 2024
概括
幼儿时期的骨周转标志物可以预测当前和未来的骨质量. 这些标记物,包括骨特异性性酸酶 (bALP) 和C端端粒交叉链 (CTX),对于评估年轻人的骨健康至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨生物学 骨生物学
- 增长和发展 增长和发展
背景情况:
- 儿童和青少年时期的骨质积累对于终身骨健康至关重要.
- 了解骨循环标记物和骨质之间的关系对于识别患有骨质不良风险的个体至关重要.
- 关于儿童和年轻人的骨周转和骨质量的纵向数据有限.
研究的目的:
- 调查血清骨循环标记物与儿童和年轻人的骨质之间的关联.
- 为了确定早期骨周转标记能否预测当前和未来的骨质量.
- 分析生长过程中骨周转标记物的基于性别的差异.
主要方法:
- 一项描述性研究跟踪了瑞典的132名儿童 (8-23岁).
- 每年测量骨质量,身高,体重和坦纳阶段.
- 血清骨形成标记物 (bALP,PINP,骨质卡尔) 和再吸收标记物 (CTX,TRAcP 5b) 在多个时间点收集.
主要成果:
- 男孩在15岁,19岁和23岁时表现出比女孩更高的骨循环标志物.
- 在早期的坦纳阶段 (10岁),bALP和TRAcP 5b与当前的骨质相关.
- 早期标记物 (bALP,PINP,骨质卡尔,CTX) 预测了随后两年的骨质变化.
结论:
- 在早期坦纳阶段测量的骨周转标记是当前骨质量的有价值的预测指标.
- 这些早期标记物也有效地预测了未来的骨质积累和变化.
- 骨循环标记的性别差异在晚年青春期和年轻成年期出现.
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