在患有精神分裂症的中国患者中,口腔真菌失生症和全身免疫功能障碍
Xia Liu1, Zongxin Ling2, Yiwen Cheng3
1Department of Intensive Care Unit, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
Translational psychiatry
|November 21, 2024
概括
精神分裂症 (SZ) 患者表现出改变的口腔真菌群落,具有更高的马拉塞西亚和更低的Candida水平. 这些变化与免疫功能障碍相关,这表明口腔真菌是SZ的潜在生物标志物.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 口腔微生物失调与精神分裂症 (SZ) 有关.
- 关于SZ口腔真菌微生物群的研究是有限的.
- 口腔真菌是口腔微生物组的关键组成部分.
研究的目的:
- 为了研究中国SZ患者的口腔真菌微生物群组成.
- 评估SZ患者宿主免疫状况.
- 探索口腔真菌和SZ中的免疫标记物之间的关系.
主要方法:
- 对118名SZ患者和97名健康对照 (HC) 的横截面研究.
- 内部转录的间隔器1个片,对舌头涂层样本进行测序以识别真菌.
- 多重免疫试验测量血清中细胞因子和化学因子水平.
主要成果:
- SZ患者的真菌丰富性减少,真菌社区结构发生变化 (β-多样性).
- 在SZ患者中观察到马拉塞西亚的水平增加和坎迪达的水平降低.
- 在SZ患者中,炎症性细胞因子 (IL-6,TNF-α) 和化学因子 (MIP-1α,MCP-1) 的含量增加.
- 马拉塞西亚与促炎性细胞因子正相关,而坎迪达与负相关.
结论:
- 改变的口腔真菌群落和全身免疫功能障碍存在于中国SZ患者中.
- 特定的口腔真菌,马拉塞西亚和甘地达,可以作为SZ. 潜在的诊断生物标志物.
- 这些发现为口腔真菌在SZ病原和免疫系统参与中的作用提供了新的见解.
相关概念视频
Fungal Group Zygomycota
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Negative and Cognitive Symptoms of Schizophrenia
44
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
44
Biological Causes of Schizophrenia
46
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
46
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
460
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
460
Schizophrenia
70
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
70


