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与生物膜相关的多药耐药和甲素耐药的金黄色葡萄球菌感染

Shila Shrestha¹, Ajaya Basnet¹, Rajendra Maharjan²

¹Department of Medical Microbiology, Shi-Gan International College of Science and Technology, Tribhuvan University, Shankhamarg, Kathmandu, Nepal.

Journal of Nepal Health Research Council

|November 22, 2024

概括

抗多药性 (MDR) 黄金葡萄球菌和抗甲素黄金葡萄球菌 (MRSA) 是难以治疗的感染的主要原因. 形成生物膜的菌株表现出比单独的MDR和MRSA更高的抗菌耐药性.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
临床研究临床研究

背景情况:

黄金葡萄球菌,包括耐甲西林菌株 (MRSA),形成生物膜,有助于慢性和难以治疗的感染.
这些多抗药性 (MDR) 感染在临床环境中带来了重大挑战.
了解这些菌株的流行率和特征对于有效的治疗策略至关重要.

研究的目的:

确定康提儿童医院黄金葡萄球菌感染的流行率.
描述MDR,MRSA和生物膜形成的S. aureus菌株的抗菌素耐药性模式.
调查这些耐药性和生物膜形成表型的共存.

主要方法:

从临床样本中分离和识别金黄色细菌.
按照标准指导方针进行抗微生物敏感性测试 (抗生素图).
使用微型板方法检测生物膜的形成.
使用SPSS版本17.0.0进行统计分析.

主要成果:

在9.0%的样本中检测到金黄色葡萄球菌,主要来自.
甲状腺病毒的MDR,MRSA和生物膜形成菌株分别占S. aureus感染的79.6%,67.6%和24.5%.
观察到高耐药率,包括84.7%的青素耐药性和18.4%的氨基糖化物耐药性.

结论:

许多MDR和MRSA菌株是导致绝大多数黄金菌感染的原因.
与非生物膜形成的MDR和MRSA菌株相比,生物膜形成菌株表现出高水平的抗菌耐药性.
这些发现凸显了治疗金黄色细菌感染的复杂挑战,特别是那些涉及耐药性和生物膜形成的感染.

关键词:

抗生素;生物膜;儿童;耐药性;金黄色葡萄球菌.

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