免疫营养指数与类风湿性关节炎的疾病活性有关:一个横截面研究
Özlem Kılıç1, Duygu Tecer1, Muhammed Canbaş1
1Gülhane Training and Research Hospital, Rheumatology Department, University of Health Sciences, Ankara, Turkey.
像CALLY和PNI这样的免疫营养指数可以帮助评估类风湿性关节炎 (RA) 疾病活动. 较低的CALLY和PNI水平与较高的RA疾病活性相关,这表明它们的预后价值.
科学领域:
- 风湿病学和免疫学
- 临床营养学 临床营养学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,其特点是关节炎症和潜在的全身并发症.
- 评估疾病活动对于有效的RA管理和预测患者结果至关重要.
- 免疫营养指数为评估疾病状况和患者预后提供了潜在的生物标志物.
研究的目的:
- 研究各种免疫营养指数与类风湿性关节炎 (RA) 患者的疾病活性水平之间的关联.
- 确定可靠的生物标志物,用于预测RA患者的疾病活性.
主要方法:
- 一项涉及116名RA患者和90名健康对照者的横截面研究.
- 根据疾病活动得分28-红细胞沉积率 (DAS 28-ESR) 将患者分为缓解或活跃疾病组.
- 评估的指数包括系统性免疫-炎症指数 (SII),控制营养状况 (CONUT),纤维素与白蛋白比率 (FAR),CRP-白蛋白-淋巴细胞比率 (CALLY) 和预后营养指数 (PNI).
主要成果:
- 与健康对照组相比,RA患者的SII,CONUT,FAR,CALLY和PNI水平显著不同.
- DAS 28-ESR显示了与PNI和CALLY的负相关性 (p < 0.001).
- 确定PNI和CALLY是疾病活动的独立标志物 (p < 0.001),CALLY对活跃疾病具有高灵敏度 (84.06%) 和特异性 (95.74%).
结论:
- 血红蛋白-白蛋白-淋巴细胞比率 (CALLY) 和预后营养指数 (PNI) 是评估类风湿性关节炎疾病活性的有价值指标.
- 这些免疫营养指数可以作为RA患者有用的预后标记,有助于临床决策.
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