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Updated: Jun 6, 2025

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通过有毒动力学建模,体外-体内外推算和新方法方法论,进一步了解人类的变异性

Anna Kreutz1,2, Xiaoqing Chang3, Helena T Hogberg4

  • 1Inotiv, 601 Keystone Park Drive, Suite 200, Morrisville, NC, 27560, USA. anna.kreutz@inotiv.com.

Human genomics
|November 22, 2024
PubMed
概括

基于生理学的毒动力学 (PBTK) 建模整合了生理学和计算方法来估计内部暴露. 这种方法通过表征变异性和支持监管决策来加强化学风险评估.

关键词:
在体外-体内活体抽外推理.生命阶段的生活阶段.新方法方法论新方法方法论基于生理学的毒动力学模型.毒动性变异性的毒动性变异性

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