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一个扩散皮质图像研究整个大脑微观结构和认知功能之间的关系在老年人轻度认知障碍

Nanae Matsumoto¹, Taiki Sugimoto^1,2, Fumio Yamashita³

¹Department of Prevention and Care Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

Acta radiologica (Stockholm, Sweden : 1987)

|November 22, 2024

概括

老年人的轻度认知障碍 (MCI) 与大脑微观结构的变化有关. 扩散皮质图像 (DKI) 显示了认知功能和灰色物质完整性之间的关联,特别是在额头和顶部区域.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
老年学是指老年学的学科.

背景情况:

通过迷你精神状态检查 (MMSE) 测量认知功能与大脑灰质微观结构之间的关系尚未完全理解.
研究这些关联对于理解老年人群的认知衰退至关重要,特别是在轻度认知障碍 (MCI) 的过渡阶段.

研究的目的:

使用扩散曲解成像 (DKI) 探索认知功能 (MMSE) 和灰色物质微观结构之间的联系.
为了检查诊断为轻度认知障碍 (MCI) 的老年人中的这些关系,并将它们与认知正常 (CN) 个体进行比较.

主要方法:

扩散性曲解成像 (DKI) 和迷你精神状态检查 (MMSE) 数据从34名患有MCI的老年人和16名认知正常人 (65-85岁) 收集.
在31个感兴趣的灰色物质区域中分析了DKI参数.
多重回归分析评估了DKI参数和MMSE得分之间的关联,相互作用分析检查了群体差异 (MCI与CN).

主要成果:

在MCI组中,在几个灰色质区域的MMSE得分和平均皮 (MK) 之间发现了显著的正相关性,包括上额头,中额头,下额头,前中,后中,角,中,下回,和上叶.
在中间的正面,前中心,后中心和角度旋转中,MK与群体状态之间的相互作用是显著的,这表明与认知功能相关的群体特定的微观结构差异.

结论:

患有MCI的老年人显示出特定大脑区域的微观结构变化的证据,例如中前额和角转移.
这些发现表明,潜在的组织学损伤有助于MCI的认知衰退,并提供了对潜在病理生理学的见解.

关键词:

大脑微观结构的大脑微观结构认知功能认知功能扩散曲解成像扫描图像轻度的认知障碍轻度的认知障碍年龄较大的成年人.

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