低水平激光疗法和类风湿性关节炎:一个系统审查和元分析研究
Amirali Salajegheh1, Fatemeh Yazdi Yahyaabadi2, Farzaneh Yazdi3
1Department of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran. aa.seljuk@gmil.com.
European journal of translational myology
|November 22, 2024
概括
低水平激光疗法 (LLLT) 对类风湿性关节炎 (RA) 患者来说是有前途的,显著改善了握力,减少了早晨的硬. 然而,这种疗法在分析的研究中没有显示出对缓解疼痛的显著影响.
科学领域:
- 类风湿病学 类风湿病学
- 物理医学和康复 康复
- 生物光子学 生物光子学
背景情况:
- 风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,导致关节炎症,疼痛,硬和功能减弱.
- 目前的RA治疗旨在控制症状并减缓疾病的进展,但许多患者会出现持续的症状.
- 低水平激光疗法 (LLLT) 是一种使用光调节细胞过程的非侵入性治疗方式,具有潜在的抗炎和止痛作用.
研究的目的:
- 系统地审查和元分析低水平激光疗法 (LLLT) 对类风湿性关节炎 (RA) 的疗效.
- 评估LLLT对关键RA症状的影响:疼痛,握力和早晨硬.
- 综合关于LLLT作为RA的辅助治疗有效性的证据.
主要方法:
- 在PubMed,Scopus和Web of Science进行了全面的文献搜索.
- 包括23项符合系统审查资格标准的研究,其中22项研究纳入了元分析.
- 用随机效应模型分析数据,以计算主要结果的集成平均差异 (MD).
主要成果:
- 与安慰剂相比,LLLT没有显著减少疼痛 (MD = 0.00,p = 0.97).
- LLLT显著改善了握力 (MD = -12.38,p < 0.01) 和减少了早晨硬 (MD = -0.84,p < 0.01).
- 在握力和早晨硬的结果中观察到大量的异质性.
结论:
- LLLT显示出作为类风湿性关节炎的辅助疗法的潜力,特别是改善握力和缓解早晨硬.
- 在这次元分析中,LLLT在RA患者的疼痛减轻方面没有显著的有效性.
- 需要进一步的研究来优化LLLT治疗方案,并阐明其在RA管理中的作用机制.
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