来自Lactobacillus Johnsonii的后生物激活了肠道天生的免疫力,以减轻与酒精有关的肝病
Ruopeng Yin1,2, Tao Wang1, Jingzu Sun1
1State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|November 22, 2024
概括
热杀死 Lactobacillus johnsonii (HKLJ) 通过恢复肠道平衡,有效治疗与酒精有关的肝病 (ALD). HKLJ调节肠肝轴,增强免疫反应,促进肝脏的修复.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 长期饮酒会导致肠道微生物群失调和免疫系统功能障碍,导致酒精相关性肝病 (ALD).
- 益生菌和后生菌干预措施在通过恢复肠道平衡来管理ALD方面表现有前途.
研究的目的:
- 为了研究热杀死Lactobacillus johnsonii (HKLJ) 在减轻酒精性肝损伤方面的有效性.
- 通过肠肝轴阐明HKLJ通过肠肝轴的保护作用的潜在机制.
主要方法:
- 使用了与酒精相关的肝病 (ALD) 的小鼠模型.
- 进行热杀死乳杆菌 (HKLJ) 的管理,并分析其对肠道微生物群组成和免疫路径的影响.
- 评估了肠道酶表达,细胞因子 (IL-23,IL-22) 和肝脏STAT3通路的激活.
主要成果:
- 在小鼠模型中,HKLJ的使用改善了酒精性肝损伤.
- HKLJ上调肠道溶酶,增强肠道细菌衍生的免疫调节物质.
- HKLJ激活了NOD2-IL-23-IL-22天生的免疫轴,促进了IL-22的产生.
- IL-22的升高促进了抗微生物合成,并激活了肝脏的STAT3通路,促进了肝脏的修复.
- HKLJ逆转了乙醇诱导的肠道微生物群失生症,减少了机会性病原体,增加了产生丁酸盐的细菌.
结论:
- 热杀死的Lactobacillus johnsonii (HKLJ) 证明了与酒精相关的肝病 (ALD) 的显著治疗潜力.
- 通过调节肠肝轴,增强先天免疫力和恢复肠道微生物平衡,HKLJ具有保护作用.
- 这些发现为ALD提供了新的治疗策略,通过准肠道微生物群和免疫系统.
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