奥西默提尼布用于不常见的内皮生长因子受体突变非小细胞肺癌:一个病例报告
Niveditha Popuri1, Vishnu Nagalapuram2, Unaiza Zaman2
1Department of General Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Case reports in oncology
|November 22, 2024
概括
在非小细胞肺癌 (NSCLC) 中,奥西默提尼布在患有罕见EGFR外基因19突变的患者中表现出持续的疾病控制. 这一案例突显了针对罕见突变的向治疗的潜在疗效,实现了26个月的无进展生存期.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 药理学 药理学是指药理学的学科.
背景情况:
- 非小细胞肺癌 (NSCLC) 是癌症死亡的主要原因.
- 包括奥西默蒂尼布在内的向疗法已经改变了NSCLC治疗.
- 奥西默蒂尼布对罕见EGFR突变的疗效在很大程度上仍未被描述.
研究的目的:
- 报告一个患有罕见EGFR外基因组19缺失插入突变的患者对奥西默蒂尼布持续反应的病例.
- 为在NSCLC中罕见EGFR突变的有限数据指导治疗做出贡献.
主要方法:
- 一名64岁的患有转移性NSCLC的妇女接受了包括成像和活检在内的诊断工作.
- 下一代测序发现了一种罕见的EGFR外19删除插入突变 (p.E746_S752delinsV).
- 患者接受了osimertinib治疗,并对反应进行了监测.
主要成果:
- 患者在开始服用 osimertinib 后的 2 周内获得了临床反应.
- 持续的疾病控制观察到26个月,导致26个月的无进展生存.
- 这种罕见的EGFR突变被osimertinib成功准.
结论:
- 这一案例证明了奥西默提尼布在患有罕见EGFR外基因19突变的患者中的潜在疗效.
- 需要进行进一步的前性研究,以评估罕见EGFR突变患者的铁氨酸激酶抑制剂.
- 确保患者安全和治疗反应在这个人群中需要进一步调查.
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