Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.1K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Self-vocalizations activate the developing auditory cortex via an intracortical pathway.

Science advances·2026
Same author

NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition.

Science advances·2026
Same author

IAN, an intelligent system for omics data analysis and discovery.

Cell reports methods·2026
Same author

The effect of the integrated stress response reduction intervention on cellular aging in middle-aged nurses: a pilot study.

BMC nursing·2026
Same author

Layer 6 corticothalamic neurons show diverse and dynamic responses that support a role in cortical gain control in noisy environments.

bioRxiv : the preprint server for biology·2026
Same author

Cell-type-specific sustained value representations in the claustrum.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: Jun 6, 2025

In Vivo Intracerebral Stereotaxic Injections for Optogenetic Stimulation of Long-Range Inputs in Mouse Brain Slices
09:07

In Vivo Intracerebral Stereotaxic Injections for Optogenetic Stimulation of Long-Range Inputs in Mouse Brain Slices

Published on: September 20, 2019

11.4K

对于小鼠新皮质中的第六层激发神经元的深层共识定义.

Su-Jeong Kim1, Travis A Babola1, Kihwan Lee1

  • 1Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA.

bioRxiv : the preprint server for biology
|November 22, 2024
PubMed
概括

定义深层6b (L6b) 神经元对于理解新皮质功能至关重要. 这项研究为L6b神经元建立了共识定义,将其与其他6层神经元区分开来,并澄清了它们独特的连接性和稳定的电生理学特性.

更多相关视频

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.3K
Multiphoton Microscopy of Cleared Mouse Brain Expressing YFP
10:03

Multiphoton Microscopy of Cleared Mouse Brain Expressing YFP

Published on: September 23, 2012

13.8K

相关实验视频

Last Updated: Jun 6, 2025

In Vivo Intracerebral Stereotaxic Injections for Optogenetic Stimulation of Long-Range Inputs in Mouse Brain Slices
09:07

In Vivo Intracerebral Stereotaxic Injections for Optogenetic Stimulation of Long-Range Inputs in Mouse Brain Slices

Published on: September 20, 2019

11.4K
Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.3K
Multiphoton Microscopy of Cleared Mouse Brain Expressing YFP
10:03

Multiphoton Microscopy of Cleared Mouse Brain Expressing YFP

Published on: September 23, 2012

13.8K

科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学

背景情况:

  • 新皮质功能依赖于精确的细胞类型定义.
  • 深层6 (L6b) 神经元与甲状腺皮层相互作用,大脑状态调节和神经精神疾病有关.
  • 之前对L6b神经元的定义缺乏共识,阻碍了研究.

研究的目的:

  • 为深层6b (L6b) 神经元建立共识定义.
  • 要将L6b神经元与其他6层神经元区分开来,例如6层皮质层神经元 (L6CThNs).
  • 描述L6b神经元发育稳定的电生理学特性.

主要方法:

  • 对L6b神经元识别的分子,转录和形态方法的比较分析.
  • 用转基因小鼠线来进行细胞类型特定的标记和分析.
  • 电生理学记录以评估内在性质和发育稳定性.

主要成果:

  • 根据综合定义方法确定了L6b神经元的核心群体.
  • 证明L6b神经元在皮层区域之间以ipsilateral方式投射,与激发感官丘脑的L6CThN不同.
  • 发现L6b神经元的内在电生理性质在出生后第一周后稳定,尽管有早期的发育变化.

结论:

  • 为L6b神经元提供共识定义,促进跨研究比较.
  • 澄清了新皮层内L6b神经元的独特连接性.
  • 确定L6b神经元电生理学的发育稳定性,有助于未来的功能研究.