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Updated: Jun 12, 2025

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

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通过转录抑制和直接CAG重复结合来抑制亨廷顿病的体质不稳定性

Ella W Mathews1,2, Sydney R Coffey2, Annette Gärtner3

  • 1Department of Neurology, University of Washington, Seattle WA 98104, USA.

bioRxiv : the preprint server for biology
|November 22, 2024
PubMed
概括

针对DNA的亨廷顿病疗法显示出减少突变亨廷丁 (HTT) 毒性和体质不稳定性 (SI) 的承诺. 结合DNA的蛋白质在不降低HTT水平的情况下保护SI,这表明了一种新的治疗策略.

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Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System10:52

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

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Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

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