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Updated: Jul 7, 2026

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
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A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

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开发一种新的N-terminomic方法来研究人类中性粒细胞中V8蛋白酶的Staphylococcus aureus的病态降解

Emilee M Mustor, Andrew M Frey, Mary-Elizabeth Jobson

    bioRxiv : the preprint server for biology
    |November 22, 2024
    PubMed
    概括

    黄金葡萄球菌V8蛋白酶向人类中性粒细胞中的350多种蛋白质,影响免疫防御,如迁移和亡. 这项研究揭示了病原体如何破坏中性粒细胞的功能以引起疾病.

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    Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...