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通过AlSE,肠道微生物利用替代甜味剂D-Allulose
Glory Minabou Ndjite1, Angela Jiang1,2, Charlotte Ravel1
1College of Computer, Mathematical and Natural Sciences, University of Maryland, College Park, Maryland, USA.
bioRxiv : the preprint server for biology
|November 22, 2024
概括
D-粉是一种低热量甜味剂替代品. 很少有肠道细菌拥有D-素-6-酸盐3-表皮酶 (AlsE) 酶,限制其在人类肠道微生物群中的代谢.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 营养科学 营养科学
背景情况:
- D-粉是一种罕见的糖甜剂,具有低热量特性.
- 像糖醇这样的替代甜味剂可能会导致胃肠道问题.
- D-氨酸-6-酸盐3-聚酶 (AlsE) 促进了 prokaryotes 中的 D-氨酸代谢.
研究的目的:
- 调查Alse酶在肠道细菌中的流行和分布.
- 了解肠道微生物组代谢D-粉素的能力.
- 评估D-allulose作为低热量甜味剂的潜力,其肠道影响最小.
主要方法:
- 细菌基因组的生物信息分析用于 AlsE 同类物.
- 在Clostridium innocuum*中对D-糖代谢的实验验证.
- 对人类肠道微生物组样本的元基因组学分析.
主要成果:
- 在85,202个基因组中,在116种细菌物种中发现了Alse同类物种,这表明分布有限.
- *Clostridium innocuum*通过其同类AlSE代谢D-粉素.
- 在分析的人类肠道微生物组中,只有15.8%含有Alse,这表明其流行程度有限.
结论:
- 肠道微生物组通过AlSE具有有限的代谢D-粉素的能力.
- D-粉可能是一个适合的低热量甜味剂,对肠道微生物群的影响最小.
- 研究结果支持个性化营养策略,以管理血糖反应和胃肠道舒适度.
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