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Updated: Jun 6, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
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Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

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长寿头的DNA修复和抗癌机制

Denis Firsanov1, Max Zacher1, Xiao Tian1

  • 1Department of Biology, University of Rochester, Rochester, NY, USA.

bioRxiv : the preprint server for biology
|November 22, 2024
PubMed
概括

弓头通过使用高效的DNA修复机制,抵御癌症,尽管它们的大小和寿命长. 这种先进的细胞修复,涉及像CIRBP这样的蛋白质,保持基因组完整性,他们的异常长期,无癌症的生活.

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Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells13:10

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DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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