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TRPV4通道有助于大动脉根硬化和动脉样硬化病变的发展

Suneha G Rahaman¹, Bidisha Dutta¹, Shaik O Rahaman¹

¹University of Maryland, Department of Nutrition and Food Science, College Park, MD 20742.

bioRxiv : the preprint server for biology

|November 22, 2024

概括

动脉硬度有助于动脉样硬化. 研究人员确定了机械敏感的短暂受体潜在化物4 (TRPV4) 通道作为细胞传感器,将矩阵度与动脉样硬化中的炎症和纤维化联系起来,这表明TRPV4是治疗点.

科学领域:

心血管生物学心血管生物学
细胞机械传导细胞机械传导
动脉样硬化研究动脉样硬化研究

背景情况:

心血管疾病,特别是动脉样硬化,是导致死亡的主要原因.
动脉硬是动脉样硬化的已知危险因素,但其潜在机制尚不清楚.
矩阵硬会影响炎症和纤维细胞活动,这表明细胞硬感应在疾病进展中的作用.

研究的目的:

研究细胞刚度感应在动脉样硬化的发展中的作用.
为了确定特定的细胞机制和分子参与者参与链接矩阵硬化与动脉样硬化病理.
在动脉样硬化背景下,探索短暂受体潜在化物4 (TRPV4) 通道作为潜在的刚度传感器.

主要方法:

使用了人类大动脉组织和小鼠动脉样.
采用原子力显微镜 (AFM) 来分析细胞的机械特性.
研究了矩阵刚度对巨细胞和纤维细胞激活以及炎症基因表达的影响.

主要成果:

确定了机械敏感的短暂受体潜在化物4 (TRPV4) 通道作为一个关键的细胞度传感器.
证明TRPV4通道调节巨细胞和纤维细胞激活,炎症和纤维化.
通过TRPV4建立了矩阵刚性,细胞机械感知和动脉样硬化的进展之间的联系.

结论:

TRPV4通道充当细胞传感器,将矩阵刚性转化为动脉样硬化的炎症和纤维性反应.
一个积极的反循环存在,炎症,纤维化和组织硬相互加强,巨细胞发挥着中心作用.
向TRPV4是一个潜在的治疗策略,可以预防或减轻动脉动脉生成.

关键词:

动脉样硬化是一种动脉样硬化.原子力显微镜原子力显微镜人类大动脉根组织鼠标模型鼠标模型暂时的受体潜力瓦尼洛伊德 4

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