昼夜时钟调节受体介导的免疫反应对草食动物相关的分子模式
Natalia Guayazán Palacios1, Takato Imaizumi1, Adam D Steinbrenner1
1Department of Biology, University of Washington, Seattle, WA, USA.
bioRxiv : the preprint server for biology
|November 22, 2024
概括
植物使用内部时钟来定时对虫攻击的防御反应. 这项研究揭示了昼夜时钟如何控制基因表达,在白天增强植物免疫力.
科学领域:
- 植物生物学 植物生物学
- 分子植物病原体相互作用
- 植物与昆虫的相互作用
背景情况:
- 植物拥有模式识别受体,可以检测与草食动物相关的分子模式 (HAMPs),从而触发防御反应.
- 昼夜时钟影响植物防御输出,但将时钟与草食动物诱导的反应联系在一起的精确分子机制尚未完全理解.
研究的目的:
- 研究植物昼夜时钟如何调节转录重编程以响应来自草食动物的线索.
- 为了描述白豆 (Vigna unguiculata) 中的毛虫衍生的In11的日间时间依赖的转录反应.
主要方法:
- 进行了日间和自由运行的实验,以评估基因表达模式.
- 在恒定的光照条件下对条件性心律失常突变的分析.
- 记者测试被用来检查时钟因子和防御基因促进体之间的相互作用.
主要成果:
- 与夜间诱导相比,白天的In11诱导导致更强的晚期诱导基因表达.
- 有节律不整的昼夜表型的植物对In11.11失去了日间时间依赖的反应.
- 生物钟基因VulHY1和VulHY2的不节律表达与时间响应的丧失有关.
- VuLHY同类物通过CCA1/LHY结合点直接调节白天In11诱导基因VUKTI的促进物.
结论:
- 植物的昼夜时钟直接调节草食动物诱导的防御基因表达的时间.
- 循环时钟转录因子,如VulHY1和VulHY2,在调解对HAMP的一天特定时间反应方面发挥着至关重要的作用.
- 这项研究阐明了一个关键的分子机制,它是植物对草食动物免疫力的时间调节的基础.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K
02:45Biological Clocks and Seasonal Responses
41.5K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.5K
02:26Defenses Against Pathogens and Herbivores
29.5K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
29.5K
01:28Inflammatory Response
16.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.0K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
354
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
354
01:25Cell Signaling in Plants
6.1K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
6.1K